Role of tubulin posttranslational modifications in development
نویسندگان
چکیده
s 44
منابع مشابه
Posttranslational Modifications of Tubulin and the Polarized Transport of Kinesin-1 in Neurons
Polarized transport by microtubule-based motors is critical for neuronal development and function. Selective translocation of the Kinesin-1 motor domain is the earliest known marker of axonal identity, occurring before morphological differentiation. Thus, Kinesin-1-mediated transport may contribute to axonal specification. We tested whether posttranslational modifications of tubulin influence t...
متن کاملMicrotubule composition: cryptography of dynamic polymers.
T he posttranslational modification of microtubules reveals additional levels of diversity within the cytoarchitecture. Modified forms of microtubules are differentially distributed in cells and harbor distinct sets of microtubule-associated proteins. It has been difficult to ascertain whether these posttranslational modifications dictate microtubule dynamics, or whether particular modification...
متن کاملThe tubulin code: Molecular components, readout mechanisms, and functions
Microtubules are cytoskeletal filaments that are dynamically assembled from α/β-tubulin heterodimers. The primary sequence and structure of the tubulin proteins and, consequently, the properties and architecture of microtubules are highly conserved in eukaryotes. Despite this conservation, tubulin is subject to heterogeneity that is generated in two ways: by the expression of different tubulin ...
متن کاملMEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons.
Neuronal migration is a fundamental process during the development of the cerebral cortex and is regulated by cytoskeletal components. Microtubule dynamics can be modulated by posttranslational modifications to tubulin subunits. Acetylation of α-tubulin at lysine 40 is important in regulating microtubule properties, and this process is controlled by acetyltransferase and deacetylase. MEC-17 is ...
متن کاملThe Tubulin Tyrosination Cycle: A Palestinian Challenge
Microtubules are hollow rod-like polymers (figure 1). They fulfill a varied range of functions including maintenance of cell integrity, forming a spindle that facilitates chromosome separation and as a protein polymer ‘track’ for intracellular transport by molecular motors such as kinesin and dynein. Each microtubule is made of 13 protofilaments consisting of linearly arranged tubulin molecules...
متن کامل